Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressant-like Effects and Reverse the Impact of Chronic Stress in Mice

@article{Burokas2017TargetingTM,
  title={Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressant-like Effects and Reverse the Impact of Chronic Stress in Mice},
  author={A. Burokas and S. Arboleya and R. D. Moloney and Veronica L. Peterson and J. Cryan},
  journal={Biological Psychiatry},
  year={2017},
  volume={82},
  pages={472-487}
}
BACKGROUND The realization that the microbiota-gut-brain axis plays a critical role in health and disease, including neuropsychiatric disorders, is rapidly advancing. Nurturing a beneficial gut microbiome with prebiotics, such as fructo-oligosaccharides (FOS) and galacto-oligosaccharides (GOS), is an appealing but underinvestigated microbiota manipulation. Here we tested whether chronic prebiotic treatment modifies behavior across domains relevant to anxiety, depression, cognition, stress… Expand
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References

SHOWING 1-10 OF 76 REFERENCES
Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat.
  • 509
  • PDF
Microbiota regulation of the Mammalian gut-brain axis.
  • 133
Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour
  • 353
  • PDF
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression
  • 582
The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner
  • 893
  • PDF
The prebiotics 3′Sialyllactose and 6′Sialyllactose diminish stressor-induced anxiety-like behavior and colonic microbiota alterations: Evidence for effects on the gut–brain axis
  • 135
  • Highly Influential
  • PDF
Bifidobacteria modulate cognitive processes in an anxious mouse strain
  • 191
The microbiome: stress, health and disease
  • 274
...
1
2
3
4
5
...