Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressant-like Effects and Reverse the Impact of Chronic Stress in Mice

  title={Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressant-like Effects and Reverse the Impact of Chronic Stress in Mice},
  author={Aurelijus Burokas and Silvia Arboleya and Rachel D Moloney and Veronica L. Peterson and Kiera Murphy and Gerard Clarke and Catherine Stanton and Timothy G. Dinan and John F. Cryan},
  journal={Biological Psychiatry},
Probiotic effects on anxiety-like behavior in animal models
Results indicate that probiotic substances of the Lactobacillus and Bifidobacterium type are effective in reducing anxiety-like behaviors in mice or rats evaluated in the elevated plus-maze, the open-field, the light-dark box, and conditioned defensive burying.
Antidepressant-Like Effects of Cistanche tubulosa Extract on Chronic Unpredictable Stress Rats Through Restoration of Gut Microbiota Homeostasis
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The novel insight into anti-inflammatory and anxiolytic effects of psychobiotics in diabetic rats: possible link between gut microbiota and brain regions
These findings demonstrated an innovative approach to the beneficial effects of psychobiotics in neuroinflammation and behavioral performance through gut microbiota changes, focusing on possible role of glial cells in gut–brain axis.
The enduring effects of early‐life stress on the microbiota–gut–brain axis are buffered by dietary supplementation with milk fat globule membrane and a prebiotic blend
Intervention with MFGM and prebiotic blend significantly impacted the composition of the microbiota as well as ameliorating some of the long‐term effects of early‐life stress.
Gut microbiota is involved in the antidepressant effects of adipose-derived mesenchymal stem cells in chronic social defeat stress mouse model
It is found that ADSCs administration significantly ameliorated CSDS-induced depression behaviors, which was accompanied by alteration in the gut microbiota, and ADSCs offer a promising therapeutic strategy for treating depression in patients.
Oral Probiotics Ameliorate the Behavioral Deficits Induced by Chronic Mild Stress in Mice via the Gut Microbiota-Inflammation Axis
Findings revealed that mice subjected to CMS exhibited anxiety- and depressive-like behaviors, along with increased interferon-γ, tumor necrosis factor-α, and indoleamine 2,3-dioxygenase-1 levels in the hippocampus, and the microbiota distinctly changed from the non-stress group and was characterized by highly diverse bacterial communities associated with significant reductions in Lactobacillus species.
Impact of Inosine on Chronic Unpredictable Mild Stress-Induced Depressive and Anxiety-Like Behaviors With the Alteration of Gut Microbiota
The results of the study indicated that inosine improved depressive and anxiety-like behaviors in adolescent mice, in conjunction with the alteration of fecal microbial composition, which may provide a novel perspective on the antidepressant effects of inOSine in children and adolescents.


Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat.
Microbiota regulation of the Mammalian gut-brain axis.
Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour
The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner
It is demonstrated that CNS neurotransmission can be profoundly disturbed by the absence of anormal gut microbiota and that this aberrant neurochemical, but not behavioural, profile is resistant to restoration of a normal gut flora in later life.
Bifidobacteria modulate cognitive processes in an anxious mouse strain
The microbiome: stress, health and disease
The concept of a microbiome–brain–gut axis is emerging which suggests that modulation of the gut microflora may be a tractable strategy for developing novel therapeutics for complex stress-related CNS disorders where there is a huge unmet medical need.
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