Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential.

@article{Bogoyevitch2004TargetingTJ,
  title={Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential.},
  author={Marie A. Bogoyevitch and Ingrid Boehm and Aaron J Oakley and Albert J Ketterman and Renae K Barr},
  journal={Biochimica et biophysica acta},
  year={2004},
  volume={1697 1-2},
  pages={89-101}
}
The c-Jun N-terminal protein kinases (JNKs) form one subfamily of the mitogen-activated protein kinase (MAPK) group of serine/threonine protein kinases. The JNKs were first identified by their activation in response to a variety of extracellular stresses and their ability to phosphorylate the N-terminal transactivation domain of the transcription factor c-Jun. One approach to study the function of the JNKs has included in vivo gene knockouts of each of the three JNK genes. Whilst loss of either… CONTINUE READING

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