Targeting the Hippo Pathway and Cancer through the TEAD Family of Transcription Factors

@inproceedings{Holden2018TargetingTH,
  title={Targeting the Hippo Pathway and Cancer through the TEAD Family of Transcription Factors},
  author={Jeffrey K. Holden and Christian N. Cunningham},
  booktitle={Cancers},
  year={2018}
}
The Hippo pathway is a critical transcriptional signaling pathway that regulates cell growth, proliferation and organ development. The transcriptional enhanced associate domain (TEAD) protein family consists of four paralogous transcription factors that function to modulate gene expression in response to the Hippo signaling pathway. Transcriptional activation of these proteins occurs upon binding to the co-activator YAP/TAZ whose entry into the nucleus is regulated by Lats1/2 kinase. In recent… CONTINUE READING

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