Targeting the HGF/c-Met axis: state of play.

In a recent issue ofMolecular Cancer Therapeutics, Burgess and colleagues (1) give a detailed biochemical and functional characterization of AMG 102, a fully humanized monoclonal antibody to hepatocyte growth factor (HGF). HGF, or scatter factor, is the only known high-affinity ligand for the c-Met receptor tyrosine kinase (2). Upon ligand binding, c-Met… CONTINUE READING