Targeting the Glutamatergic System for the Treatment of HIV-Associated Neurocognitive Disorders

@inproceedings{Potter2013TargetingTG,
  title={Targeting the Glutamatergic System for the Treatment of HIV-Associated Neurocognitive Disorders},
  author={Michelle C. Potter and Mariana Figuera-Losada and Camilo Rojas and Barbara S Slusher},
  booktitle={Journal of Neuroimmune Pharmacology},
  year={2013}
}
The accumulation of excess glutamate in the extracellular space as a consequence of CNS trauma, neurodegenerative diseases, infection, or deregulation of glutamate clearance results in neuronal damage by excessive excitatory neurotransmission. Glutamate excitotoxicity is thought to be one of several mechanisms by which HIV exerts neurotoxicity that culminates in HIV-associated neurocognitive disorders (HAND). Excess glutamate is released upon HIV infection of macrophage/microglial cells and has… CONTINUE READING
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