Targeting the Giant Cell Tumor Stromal Cell: Functional Characterization and a Novel Therapeutic Strategy

@inproceedings{Steensma2013TargetingTG,
  title={Targeting the Giant Cell Tumor Stromal Cell: Functional Characterization and a Novel Therapeutic Strategy},
  author={Matthew Richard Steensma and Wakenda K. Tyler and Allison G. Shaber and Steven Robert Goldring and Frederick Ross and Bart O. Williams and John H. Healey and P. Edward Purdue},
  booktitle={PloS one},
  year={2013}
}
Giant cell tumor of bone (GCTB) is a benign, locally destructive neoplasm, with tumors comprised of mesenchymal fibroblast-like stromal cells; monocytic, mononuclear cells of myeloid lineage; and the characteristic osteoclast-like, multinucleated giant cells. Hampering the study of the complex interaction of its constituent cell types is the propensity of longstanding, repeatedly passaged cell cultures to undergo phenotypic alteration and loss of osteoclast-inducing capacities. In this study… CONTINUE READING

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