Targeting the ER-autophagy system in the trabecular meshwork to treat glaucoma.

@article{Stothert2016TargetingTE,
  title={Targeting the ER-autophagy system in the trabecular meshwork to treat glaucoma.},
  author={Andrew R Stothert and Sarah N. Fontaine and Jonathan J. Sabbagh and Chad A Dickey},
  journal={Experimental eye research},
  year={2016},
  volume={144},
  pages={38-45}
}
A major drainage network involved in aqueous humor dynamics is the conventional outflow pathway, which is gated by the trabecular meshwork (TM). The TM acts as a molecular sieve, providing resistance to aqueous outflow, which is responsible for regulating intraocular pressure (IOP). If the TM is damaged, aqueous outflow is impaired, IOP increases and glaucoma can manifest. Mutations in the MYOC gene cause hereditary primary open-angle glaucoma (POAG) by promoting the abnormal amyloidosis of the… CONTINUE READING
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