Targeting the Cerebellum by Noninvasive Neurostimulation: a Review

  title={Targeting the Cerebellum by Noninvasive Neurostimulation: a Review},
  author={Kim van Dun and Florian Bodranghien and Mario Manto and Peter Mari{\"e}n},
  journal={The Cerebellum},
Transcranial magnetic and electric stimulation of the brain are novel and highly promising techniques currently employed in both research and clinical practice. Improving or rehabilitating brain functions by modulating excitability with these noninvasive tools is an exciting new area in neuroscience. Since the cerebellum is closely connected with the cerebral regions subserving motor, associative, and affective functions, the cerebello-thalamo-cortical pathways are an interesting target for… 
Cerebellar Cortex as a Therapeutic Target for Neurostimulation
The potentials of cerebellar neuromodulation in major brain disorders is discussed in order to encourage large-scale sham-controlled research and explore this therapeutic aid further.
Non-invasive Cerebellar Stimulation: Moving Towards Clinical Applications for Cerebellar and Extra-Cerebellar Disorders
A common research effort is required to extract the optimal parameters of stimulation and to identify how non-invasive stimulation of the cerebellum modifies cerebellar plasticity and functional connectivity in remote cortical and subcortical areas.
A Brief History of Cerebellar Neurostimulation.
A brief historical account of cerebellar neurostimulation is provided and current challenges and future direction in this field of research are discussed.
Targeting the Human Cerebellum with Transcranial Direct Current Stimulation to Modulate Behavior: a Meta-Analysis
Findings establish the feasibility to target motor and non-motor-related cerebellar functions with tDCS, but arguably due to anatomical differences between the cerebellum and cerebral cortex, the polarity of tDCS is not predictive of the direction of the behavioral changes in healthy volunteers.
Non-invasive Cerebellar Stimulation: a Promising Approach for Stroke Recovery?
Mechanisms of plasticity in the cortico-cerebellar system after stroke, methods for non-invasive cerebellar stimulation, and possible target symptoms in stroke, like fine motor deficits, gait disturbance, or cognitive impairments are reviewed, and strategies for multi-focal stimulation are discussed.
Mini-review: Transcranial Alternating Current Stimulation and the Cerebellum.
An overview on this emerging electrophysiological technique CB-tACS will contribute in the further deciphering of cerebellar oscillatory signatures and its role for motor, cognitive, or affective functions and could develop into a therapeutic tool for retuning disturbed oscillatory activity in cerebellars underlying brain disorders.
Cerebello-Cortical Coherence of Local Field Potentials following Patterned Stimulation of the Cerebellar Vermis
It is found here that cerebellar stimulation can drive synchronization of cerebello-cortical and cortico- cortical networks, and the present results could provide basic mechanisms underlying the therapeutic effects of cereBellar stimulation by promoting large-scale synchronization of neural networks.


Repetitive transcranial magnetic stimulation: a tool for human cerebellar plasticity.
  • G. Koch
  • Biology, Psychology
    Functional neurology
  • 2010
Recent studies seem to indicate that long-lasting modifications of cerebellar pathways could be usefully exploited in the treatment of several pathological conditions characterized by altered cortical excitability, such as Parkinson's disease, stroke, depression and schizophrenia.
Non-invasive Cerebellar Stimulation—a Consensus Paper
There is a consensus amongst the panel of experts that both TMS and tDCS can effectively influence cerebellar functions, not only in the motor domain, with effects on visually guided tracking tasks, motor surround inhibition, motor adaptation and learning, but also for the cognitive and affective operations handled by the cerebro-cerebellar circuits.
Cerebellar Transcranial Direct Current Stimulation (ctDCS)
Transcranial direct current stimulation of the cerebellum (ctDCS) promises to be a powerful tool for the modulation of cerebellar excitability and has a good safety profile; similar to when applied over cerebral areas.
Cerebellar Stimulation in Ataxia
A conditioning stimulus over the cerebellum preceding a test stimulus of the contralateral M1 enables us to study the Cerebellar regulatory functions on M1 and its usefulness as a diagnostic tool in clinical neurophysiology.
Understanding and Modulating Motor Learning with Cerebellar Stimulation
  • P. Celnik
  • Biology, Psychology
    The Cerebellum
  • 2014
Some of the current evidence demonstrating the effects of cerebellar stimulation to modulate motor behaviour and its use to assess physiological processes underlying motor learning is presented.
A framework for targeting alternative brain regions with repetitive transcranial magnetic stimulation in the treatment of depression.
Evidence from electroencephalography and lesion studies suggests that not only is the left PFC involved in depression but also the parietal cortex and cerebellum, and an rTMS-oriented theoretical framework for the neurobiology of low mood and depression is integrated.
Brain stimulation studies of non-motor cerebellar function: A systematic review
Modulating cerebello-thalamocortical pathways by neuronavigated cerebellar repetitive transcranial stimulation (rTMS)
Polarizing cerebellar neurons with transcranial Direct Current Stimulation
A technical guide to tDCS, and related non-invasive brain stimulation tools