Targeting the Cerebellum by Noninvasive Neurostimulation: a Review

@article{Dun2016TargetingTC,
  title={Targeting the Cerebellum by Noninvasive Neurostimulation: a Review},
  author={Kim van Dun and Florian Bodranghien and Mario Manto and Peter Mari{\"e}n},
  journal={The Cerebellum},
  year={2016},
  volume={16},
  pages={695-741}
}
Transcranial magnetic and electric stimulation of the brain are novel and highly promising techniques currently employed in both research and clinical practice. Improving or rehabilitating brain functions by modulating excitability with these noninvasive tools is an exciting new area in neuroscience. Since the cerebellum is closely connected with the cerebral regions subserving motor, associative, and affective functions, the cerebello-thalamo-cortical pathways are an interesting target for… 
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Non-invasive Cerebellar Stimulation: Moving Towards Clinical Applications for Cerebellar and Extra-Cerebellar Disorders
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A common research effort is required to extract the optimal parameters of stimulation and to identify how non-invasive stimulation of the cerebellum modifies cerebellar plasticity and functional connectivity in remote cortical and subcortical areas.
A Brief History of Cerebellar Neurostimulation.
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A brief historical account of cerebellar neurostimulation is provided and current challenges and future direction in this field of research are discussed.
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Mechanisms of plasticity in the cortico-cerebellar system after stroke, methods for non-invasive cerebellar stimulation, and possible target symptoms in stroke, like fine motor deficits, gait disturbance, or cognitive impairments are reviewed, and strategies for multi-focal stimulation are discussed.
Moving back in the brain to drive the field forward: Targeting neurostimulation to different brain regions in animal models of depression and neurodegeneration
Mini-review: Transcranial Alternating Current Stimulation and the Cerebellum.
TLDR
An overview on this emerging electrophysiological technique CB-tACS will contribute in the further deciphering of cerebellar oscillatory signatures and its role for motor, cognitive, or affective functions and could develop into a therapeutic tool for retuning disturbed oscillatory activity in cerebellars underlying brain disorders.
Effects of cerebellar transcranial direct current stimulation on cerebellar-brain inhibition in humans: A systematic evaluation
Cerebello-Cortical Coherence of Local Field Potentials following Patterned Stimulation of the Cerebellar Vermis
TLDR
It is found here that cerebellar stimulation can drive synchronization of cerebello-cortical and cortico- cortical networks, and the present results could provide basic mechanisms underlying the therapeutic effects of cereBellar stimulation by promoting large-scale synchronization of neural networks.
Safety Considerations for Cerebellar Theta Burst Stimulation.
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References

SHOWING 1-10 OF 239 REFERENCES
Repetitive transcranial magnetic stimulation: a tool for human cerebellar plasticity.
  • G. Koch
  • Biology, Psychology
    Functional neurology
  • 2010
TLDR
Recent studies seem to indicate that long-lasting modifications of cerebellar pathways could be usefully exploited in the treatment of several pathological conditions characterized by altered cortical excitability, such as Parkinson's disease, stroke, depression and schizophrenia.
Non-invasive Cerebellar Stimulation—a Consensus Paper
TLDR
There is a consensus amongst the panel of experts that both TMS and tDCS can effectively influence cerebellar functions, not only in the motor domain, with effects on visually guided tracking tasks, motor surround inhibition, motor adaptation and learning, but also for the cognitive and affective operations handled by the cerebro-cerebellar circuits.
Cerebellar Transcranial Direct Current Stimulation (ctDCS)
TLDR
Transcranial direct current stimulation of the cerebellum (ctDCS) promises to be a powerful tool for the modulation of cerebellar excitability and has a good safety profile; similar to when applied over cerebral areas.
Cerebellar Stimulation in Ataxia
TLDR
A conditioning stimulus over the cerebellum preceding a test stimulus of the contralateral M1 enables us to study the Cerebellar regulatory functions on M1 and its usefulness as a diagnostic tool in clinical neurophysiology.
Understanding and Modulating Motor Learning with Cerebellar Stimulation
  • P. Celnik
  • Biology, Psychology
    The Cerebellum
  • 2014
TLDR
Some of the current evidence demonstrating the effects of cerebellar stimulation to modulate motor behaviour and its use to assess physiological processes underlying motor learning is presented.
A framework for targeting alternative brain regions with repetitive transcranial magnetic stimulation in the treatment of depression.
TLDR
Evidence from electroencephalography and lesion studies suggests that not only is the left PFC involved in depression but also the parietal cortex and cerebellum, and an rTMS-oriented theoretical framework for the neurobiology of low mood and depression is integrated.
Brain stimulation studies of non-motor cerebellar function: A systematic review
Modulating cerebello-thalamocortical pathways by neuronavigated cerebellar repetitive transcranial stimulation (rTMS)
Polarizing cerebellar neurons with transcranial Direct Current Stimulation
A technical guide to tDCS, and related non-invasive brain stimulation tools
...
...