Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance

@inproceedings{Dogovski2015TargetingTC,
  title={Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance},
  author={Con Dogovski and Stanley C Xie and Gaetan Burgio and Jess Bridgford and Sachel Mok and James M. McCaw and Kesinee Chotivanich and Shannon Kenny and Nina F Gn{\"a}dig and Judith Straimer and Zbynek Bozdech and David A. Fidock and Julie A Simpson and Arjen Mattheus Dondorp and Simon Foote and Nectarios Klonis and Leann Tilley},
  booktitle={PLoS biology},
  year={2015}
}
Successful control of falciparum malaria depends greatly on treatment with artemisinin combination therapies. Thus, reports that resistance to artemisinins (ARTs) has emerged, and that the prevalence of this resistance is increasing, are alarming. ART resistance has recently been linked to mutations in the K13 propeller protein. We undertook a detailed kinetic analysis of the drug responses of K13 wild-type and mutant isolates of Plasmodium falciparum sourced from a region in Cambodia (Pailin… CONTINUE READING
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