Targeting the CXCR4-CXCL12 axis mobilizes autologous hematopoietic stem cells and prolongs islet allograft survival via programmed death ligand 1.

@article{Fiorina2011TargetingTC,
  title={Targeting the CXCR4-CXCL12 axis mobilizes autologous hematopoietic stem cells and prolongs islet allograft survival via programmed death ligand 1.},
  author={Paolo Fiorina and Mollie M Jurewicz and Andrea Vergani and Alessandra Petrelli and Michele Carvello and Francesca D'Addio and Jonathan G. Godwin and Kenneth Wai Kit Law and Erxi Wu and Ze Tian and Gebhard Thoma and Jiř{\'i} Kovař{\'i}k and Stefano La Rosa and Carlo Renato Capella and Scott J. Rodig and Hans-Guenter Zerwes and Mohammed H. Sayegh and R. Ahmad Firdaus Abdi},
  journal={Journal of immunology},
  year={2011},
  volume={186 1},
  pages={
          121-31
        }
}
Antagonism of CXCR4 disrupts the interaction between the CXCR4 receptor on hematopoietic stem cells (HSCs) and the CXCL12 expressed by stromal cells in the bone marrow, which subsequently results in the shedding of HSCs to the periphery. Because of their profound immunomodulatory effects, HSCs have emerged as a promising therapeutic strategy for autoimmune disorders. We sought to investigate the immunomodulatory role of mobilized autologous HSCs, via target of the CXCR4-CXL12 axis, to promote… CONTINUE READING
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