Targeting the CXCR4/CXCL12 axis in systemic lupus erythematosus.

  title={Targeting the CXCR4/CXCL12 axis in systemic lupus erythematosus.},
  author={B F Chong and Chandra Mohan},
  journal={Expert opinion on therapeutic targets},
  volume={13 10},
BACKGROUND CXCR4 antagonists have garnered much interest as promising treatments for cancer metastases and HIV. Given its ability to attract multiple leukocyte subsets and stimulate B cell production and myelopoeisis, recent attention has been directed to these inhibitors in the treatment of autoimmune diseases, such as systemic lupus erythematosus (SLE). OBJECTIVE To assess the potential of CXCR4 antagonists in SLE. METHODS We reviewed literature on the expression of CXCR4 and its ligand… CONTINUE READING


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