Targeting the Androgen Receptor by Taxol in Castration-Resistant Prostate Cancer.

@article{Jiang2010TargetingTA,
  title={Targeting the Androgen Receptor by Taxol in Castration-Resistant Prostate Cancer.},
  author={Jing-ting Jiang and Haojie Huang},
  journal={Molecular and cellular pharmacology},
  year={2010},
  volume={2 1},
  pages={1-5}
}
Both cell culture and clinical studies show that the androgen receptor (AR) plays a key role in the growth and survival of castration-resistant prostate cancer (CRPC), a lethal form of the disease in the clinic, suggesting that AR remains to be a major target for the treatment of CRPC. Taxol chemotherapy is one of the few therapeutic options for patients with CRPC albeit the underlying mechanism is not fully understood. We have demonstrated recently that Taxol (paclitaxel and its semisynthetic… CONTINUE READING

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