Targeting the ANGPT–TIE2 pathway in malignancy

  title={Targeting the ANGPT–TIE2 pathway in malignancy},
  author={Hanhua Huang and Abhijit D Bhat and Gary Woodnutt and Rodney W. Lappe},
  journal={Nature Reviews Cancer},
Angiopoietins (ANGPTs) are ligands of the endothelial cell receptor TIE2 and have crucial roles in the tumour angiogenic switch. Increased expression of ANGPT2 relative to ANGPT1 in tumours correlates with poor prognosis. The biological effects of the ANGPT–TIE system are context dependent, which brings into question what the best strategy is to target this pathway. This Review presents an encompassing picture of what we know about this important axis in tumour biology. The various options for… CONTINUE READING
Highly Influential
This paper has highly influenced 21 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.
136 Citations
161 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 136 extracted citations


Publications referenced by this paper.
Showing 1-10 of 161 references

Bispecific anti - human VeGF / angiopoietin 2 antibodies for treating cancer and vascular diseases

  • G. Niu, W. B. Carter
  • 2010

First - inhuman doseescalation safety and PK trial of a novel intravenous humanized monoclonal CovX body inhibiting angiopoietin 2

  • L. S. Rosen
  • J . Clin . Oncol . Abstr .
  • 2010

Phase 1 study of AMG 386 , a selective angiopoietin 1 / 2neutralizing peptibody , in combination with chemotherapy in adults with advanced solid tumors

  • A. C. Mita
  • Clin . Cancer Res .
  • 2010

Similar Papers

Loading similar papers…