Targeting the A2B adenosine receptor during gastrointestinal ischemia and inflammation.

  title={Targeting the A2B adenosine receptor during gastrointestinal ischemia and inflammation.},
  author={Holger K. Eltzschig and Jes{\'u}s Rivera-Nieves and Sean P Colgan},
  journal={Expert opinion on therapeutic targets},
  volume={13 11},
Extracellular adenosine functions as an endogenous distress signal via activation of four distinct adenosine receptors (A1, A2A, A2B and A3). Conditions of limited oxygen availability or acute inflammation lead to elevated levels of extracellular adenosine and enhanced signaling events. This relates to a combination of four mechanisms: i) increased production of adenosine via extracellular phosphohydrolysis of precursor molecules (particularly ATP and ADP); ii) increased expression and… CONTINUE READING


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