Targeting stromal androgen receptor suppresses prolactin-driven benign prostatic hyperplasia (BPH).

@article{Lai2013TargetingSA,
  title={Targeting stromal androgen receptor suppresses prolactin-driven benign prostatic hyperplasia (BPH).},
  author={Kuo-Pao Lai and Chiung-Kuei Huang and Lei-Ya Fang and Kouji Izumi and Chi-Wen Lo and Ronald C Wood and Jon Kindblom and Shuyuan Yeh and Chawnshang Chang},
  journal={Molecular endocrinology},
  year={2013},
  volume={27 10},
  pages={1617-31}
}
Stromal-epithelial interaction plays a pivotal role to mediate the normal prostate growth, the pathogenesis of benign prostatic hyperplasia (BPH), and prostate cancer development. Until now, the stromal androgen receptor (AR) functions in the BPH development, and the underlying mechanisms remain largely unknown. Here we used a genetic knockout approach to ablate stromal fibromuscular (fibroblasts and smooth muscle cells) AR in a probasin promoter-driven prolactin transgenic mouse model (Pb-PRL… CONTINUE READING

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