Targeting striatal cholinergic interneurons in Parkinson’s disease: Focus on metabotropic glutamate receptors

@article{Pisani2003TargetingSC,
  title={Targeting striatal cholinergic interneurons in Parkinson’s disease: Focus on metabotropic glutamate receptors},
  author={Antonio Pisani and Paola Bonsi and Diego Centonze and Paolo Gubellini and Paolo Calabresi},
  journal={Neuropharmacology},
  year={2003},
  volume={45},
  pages={45-56}
}
In the early sixties, anticholinergic drugs were introduced in the pharmacological treatment of Parkinson's disease (PD). The rationale behind their utilisation in the treatment of the disease was based on the evidence of an imbalance between the dopaminergic inputs and the intrinsic cholinergic innervation within the striatum. Metabotropic glutamate (mGlu) receptors have been shown to play a key role in striatal function both in physiological conditions and in experimental models of diseases… CONTINUE READING

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