Targeting sphingosine-1-phosphate receptors in cancer.

  title={Targeting sphingosine-1-phosphate receptors in cancer.},
  author={Rebecca J. Watters and Hong-Gang Wang and Shen-Shu Sung and Thomas P. Loughran and Xin Lei Liu},
  journal={Anti-cancer agents in medicinal chemistry},
  volume={11 9},
Sphingosine 1-phosphate (S1P) is a bioactive lipid with diverse biological functions, including cell proliferation, differentiation, angiogenesis, chemotaxis, and migration. Many of the activities of S1P are mediated through five closely related G-protein-coupled receptors of the sphingosine-1-phosphate receptor family (S1PR) which play a crucial role in sphingolipid metabolism. Each of these receptors appears to be tissue specific and to have demonstrated roles in the regulation of cell… CONTINUE READING

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