Targeting sphingolipid metabolism in the treatment of obesity/type 2 diabetes.

INTRODUCTION Obesity is a major factor that is linked to the development of type 2 diabetes (T2D). Excess circulating fatty acids (FAs), which characterize obesity, induce insulin resistance, steatosis, β cells dysfunction and apoptosis. These deleterious effects have been defined as lipotoxicity. AREAS COVERED FAs are metabolized to different lipid… CONTINUE READING