Targeting sphingolipid metabolism as an approach for combination therapies in haematological malignancies

@inproceedings{Lewis2018TargetingSM,
  title={Targeting sphingolipid metabolism as an approach for combination therapies in haematological malignancies},
  author={Alexander C Lewis and Craig T Wallington-Beddoe and Jason A. Powell and Stuart M Pitson},
  booktitle={Cell Death Discovery},
  year={2018}
}
Conventional chemotherapy-based drug combinations have, until recently, been the backbone of most therapeutic strategies for cancer. In a time of emerging rationale drug development, targeted therapies are beginning to be added to traditional chemotherapeutics to synergistically enhance clinical responses. Of note, the importance of pro-apoptotic ceramide in mediating the anti-cancer effects of these therapies is becoming more apparent. Furthermore, reduced cellular ceramide in favour of pro… CONTINUE READING