Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?

  title={Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?},
  author={Carles Cant{\'o} and Johan Auwerx},
  journal={Pharmacological reviews},
  volume={64 1},
Sirtuin 1 (SIRT1) is an evolutionarily conserved NAD(+)-dependent deacetylase that is at the pinnacle of metabolic control, all the way from yeast to humans. SIRT1 senses changes in intracellular NAD(+) levels, which reflect energy level, and uses this information to adapt the cellular energy output such that it matches cellular energy requirements. The changes induced by SIRT1 activation are generally (but not exclusively) transcriptional in nature and are related to an increase in… CONTINUE READING
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