Targeting sirtuin-1 in Huntington's disease: rationale and current status.

  title={Targeting sirtuin-1 in Huntington's disease: rationale and current status.},
  author={Wenzhen Duan},
  journal={CNS drugs},
  volume={27 5},
Huntington's disease (HD) is an autosomal dominant hereditary disease caused by a trinucleotide repeat mutation in the huntingtin gene that results in an increased number of glutamine residues in the N terminus of huntingtin protein. Mutant huntingtin leads to progressive impairment of motor function, cognitive dysfunction, and neuropsychiatric disturbance. There are no disease-modifying treatments available. During the past decade, sirtuin-1 (SIRT1) has been the focus of intense investigation… CONTINUE READING
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