Targeting signal and subcellular compartments involved in the intracellular trafficking of HLA-DMB.

@article{Copier1996TargetingSA,
  title={Targeting signal and subcellular compartments involved in the intracellular trafficking of HLA-DMB.},
  author={John P. Copier and Monique J. Kleijmeer and Sreenivasan Ponnambalam and Viola Oorschot and Paul Potter and John Trowsdale and Audrey Kelly},
  journal={Journal of immunology},
  year={1996},
  volume={157 3},
  pages={1017-27}
}
Evidence suggests that peptide loading onto MHC class II molecules occurs in a specialized late endocytic compartment (MIIC) where HLA-DM predominantly resides and in which MHC class II transiently accumulates before transport to the cell surface. We examined the targeting signals and compartments involved in the intracellular trafficking of human HLA-DM by expressing hybrid molecules comprising the cytoplasmic domain of DMB and luminal and transmembrane domains of CD8 in HeLa cells. A tyrosine… CONTINUE READING