Targeting sarcoma tumor-initiating cells through differentiation therapy.

Abstract

Human leukocyte antigen class I (HLA-I) down-regulation has been reported in many human cancers to be associated with poor clinical outcome. However, its connection to tumor-initiating cells (TICs) remains unknown. In this study, we report that HLA-I is down-regulated in a subpopulation of cells that have high tumor initiating capacity in different types of… (More)
DOI: 10.1016/j.scr.2017.04.004

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