Targeting ribosomal S-6 kinase for the prevention and treatment of liver injury and liver fibrosis.


Activation of hepatic stellate cells (HSC) is responsible for the development of liver fibrosis in chronic liver diseases of all causes, and remarkably, HSC clearance by apoptosis may allow recovery from liver injury and reversal of liver fibrosis. Because in preclinical studies it has been shown that activation of ribosomal S-6 kinase (RSK) and… (More)
DOI: 10.1358/dnp.2008.21.6.1246796


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