Targeting repulsive guidance molecule A to promote regeneration and neuroprotection in multiple sclerosis.

@article{Demicheva2015TargetingRG,
  title={Targeting repulsive guidance molecule A to promote regeneration and neuroprotection in multiple sclerosis.},
  author={Elena Demicheva and Yi-Fang Cui and Philip D. Bardwell and Stefan Barghorn and Martina Kron and Axel H. Meyer and Martin Schmidt and Bjoern Gerlach and Mary Leddy and Eve H Barlow and Elizabeth O'Connor and Chee-Ho Choi and Lili Huang and Geertruida M Veldman and Horea G Rus and Alireza P Shabanzadeh and Nardos G. Tassew and Philippe P. Monnier and Thomas Mueller and Peter A. Calabresi and Hans Schoemaker and Bernhard K. Mueller},
  journal={Cell reports},
  year={2015},
  volume={10 11},
  pages={1887-98}
}
Repulsive guidance molecule A (RGMa) is a potent inhibitor of neuronal regeneration and a regulator of cell death, and it plays a role in multiple sclerosis (MS). In autopsy material from progressive MS patients, RGMa was found in active and chronic lesions, as well as in normal-appearing gray and white matter, and was expressed by cellular meningeal infiltrates. Levels of soluble RGMa in the cerebrospinal fluid were decreased in progressive MS patients successfully treated with intrathecal… CONTINUE READING
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