Targeting regulatory T cells in cancer.

  title={Targeting regulatory T cells in cancer.},
  author={William L. Byrne and Kingston H G Mills and James A. Lederer and Gerald C O'sullivan},
  journal={Cancer research},
  volume={71 22},
Infiltration of tumors by regulatory T cells confers growth and metastatic advantages by inhibiting antitumor immunity and by production of receptor activator of NF-κB (RANK) ligand, which may directly stimulate metastatic propagation of RANK-expressing cancer cells. Modulation of regulatory T cells can enhance the efficacy of cancer immunotherapy. Strategies include depletion, interference with function, inhibition of tumoral migration, and exploitation of T-cell plasticity. Problems with… CONTINUE READING

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