Targeting regulation of ABc Transporters at the Blood-Brain Barrier to improve Pharmacotherapy of cNs Disorders

@inproceedings{Bauer2010TargetingRO,
  title={Targeting regulation of ABc Transporters at the Blood-Brain Barrier to improve Pharmacotherapy of cNs Disorders},
  author={Bjoern Bauer},
  year={2010}
}
The blood-brain barrier is the capillary endothelium between blood and brain that controls what goes in and comes out of the cNs. one major factor contributing to barrier function is a group of ATP-binding cassette (ABC) drug efflux transporters that restrict brain uptake of xenobiotics including a large number of cNs therapeutics. recent research has focused on the regulation of these transporters with the goal of finding the molecular switches to selectively modulate transporter expression… CONTINUE READING

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