Targeting receptor tyrosine kinase signaling in acute myeloid leukemia.

@article{Doepfner2007TargetingRT,
  title={Targeting receptor tyrosine kinase signaling in acute myeloid leukemia.},
  author={Kathrin T. Doepfner and Danielle Boller and Alexandre Arcaro},
  journal={Critical reviews in oncology/hematology},
  year={2007},
  volume={63 3},
  pages={215-30}
}
Acute myeloid leukemia (AML) is a quickly progressing, heterogeneous clonal disorder of hematopoietic progenitor cells. Significant progress in understanding the pathogenesis of AML has been achieved in the past few years. Two major types of genetic events are thought to give rise to leukemic transformation: alterations in the activity of transcription factors controlling hematopoietic differentiation and activation of components of receptor tyrosine kinase (RTK) signaling pathways. This has… CONTINUE READING

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