Targeting reactive oxygen species, reactive nitrogen species and inflammation in MPTP neurotoxicity and Parkinson’s disease

@article{Yokoyama2008TargetingRO,
  title={Targeting reactive oxygen species, reactive nitrogen species and inflammation in MPTP neurotoxicity and Parkinson’s disease},
  author={Hironori Yokoyama and Hayato Kuroiwa and Ryohei Yano and Tsutomu Araki},
  journal={Neurological Sciences},
  year={2008},
  volume={29},
  pages={293-301}
}
Parkinson’s disease (PD) is the second most frequent neurodegenerative disorder after Alzheimer’s disease. The main clinical features of PD include tremor, bradykinesia, rigidity and postural instability. The primary pathology of PD is degeneration of dopaminergic neurons in the substantia nigra pars compacta, resulting in loss of the nigrostriatal pathway and a reduction of dopamine contents in the striatum. The biochemical and cellular changes that occur following the administration of 1… CONTINUE READING

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Parkinson ’s disease ( PD ) is the second most frequent neurodegenerative disorder after Alzheimer ’s disease .
Parkinson ’s disease ( PD ) is the second most frequent neurodegenerative disorder after Alzheimer ’s disease .
Recently , there is convincing evidence for the involvement of nitric oxide that reacts with superoxide to produce peroxynitrite and ultimately hydroxyl radical production .
Recently , there is convincing evidence for the involvement of nitric oxide that reacts with superoxide to produce peroxynitrite and ultimately hydroxyl radical production .
Recently , there is convincing evidence for the involvement of nitric oxide that reacts with superoxide to produce peroxynitrite and ultimately hydroxyl radical production .
Recently , there is convincing evidence for the involvement of nitric oxide that reacts with superoxide to produce peroxynitrite and ultimately hydroxyl radical production .
Recently , there is convincing evidence for the involvement of nitric oxide that reacts with superoxide to produce peroxynitrite and ultimately hydroxyl radical production .
Recently , there is convincing evidence for the involvement of nitric oxide that reacts with superoxide to produce peroxynitrite and ultimately hydroxyl radical production .
Parkinson ’s disease ( PD ) is the second most frequent neurodegenerative disorder after Alzheimer ’s disease .
The primary pathology of PD is degeneration of dopaminergic neurons in the substantia nigra pars compacta , resulting in loss of the nigrostriatal pathway and a reduction of dopamine contents in the striatum .
Substantia nigra structureIs location of anatomic structurePars Compacta
The primary pathology of PD is degeneration of dopaminergic neurons in the substantia nigra pars compacta , resulting in loss of the nigrostriatal pathway and a reduction of dopamine contents in the striatum .
Recently , there is convincing evidence for the involvement of nitric oxide that reacts with superoxide to produce peroxynitrite and ultimately hydroxyl radical production .
Recently , there is convincing evidence for the involvement of nitric oxide that reacts with superoxide to produce peroxynitrite and ultimately hydroxyl radical production .
Recently , there is convincing evidence for the involvement of nitric oxide that reacts with superoxide to produce peroxynitrite and ultimately hydroxyl radical production .
Recently , there is convincing evidence for the involvement of nitric oxide that reacts with superoxide to produce peroxynitrite and ultimately hydroxyl radical production .
The primary pathology of PD is degeneration of dopaminergic neurons in the substantia nigra pars compacta , resulting in loss of the nigrostriatal pathway and a reduction of dopamine contents in the striatum .
The primary pathology of PD is degeneration of dopaminergic neurons in the substantia nigra pars compacta , resulting in loss of the nigrostriatal pathway and a reduction of dopamine contents in the striatum .
The primary pathology of PD is degeneration of dopaminergic neurons in the substantia nigra pars compacta , resulting in loss of the nigrostriatal pathway and a reduction of dopamine contents in the striatum .
Parkinson ’s disease ( PD ) is the second most frequent neurodegenerative disorder after Alzheimer ’s disease .
Parkinson ’s disease ( PD ) is the second most frequent neurodegenerative disorder after Alzheimer ’s disease .
Parkinson ’s disease ( PD ) is the second most frequent neurodegenerative disorder after Alzheimer ’s disease .
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