Targeting protein kinases

  title={Targeting protein kinases},
  author={Irena Melnikova and James Golden},
  journal={Nature Reviews Drug Discovery},
NATURE REVIEWS | DRUG DISCOVERY VOLUME 3 | DECEMBER 2004 | 993 Protein kinases are considered to be the second most important group of drug targets after G-protein-coupled receptors.Aberrant kinase activity is implicated in a variety of human diseases, in particular those involving inflammatory or proliferative responses, such as cancer, rheumatoid arthritis, cardiovascular and neurological disorders, asthma and psoriasis. Directly or indirectly, more than 400 human diseases have been connected… CONTINUE READING