Targeting protein kinase C by Enzastaurin restrains proliferation and secretion in human pancreatic endocrine tumors.

Abstract

Dysregulation of the protein kinase C (PKC) signaling pathway has been implicated in tumor progression. In this study, we investigate the effects of a PKC inhibitor, Enzastaurin, in human pancreatic neuroendocrine neoplasms (PNN) primary cultures and in the human pancreatic endocrine cancer cell line, BON1. To this aim six human PNN dispersed in primary… (More)
DOI: 10.1530/ERC-11-0055

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