Targeting protein homeostasis in sporadic inclusion body myositis.

Abstract

Sporadic inclusion body myositis (sIBM) is the commonest severe myopathy in patients more than 50 years of age. Previous therapeutic trials have targeted the inflammatory features of sIBM but all have failed. Because protein dyshomeostasis may also play a role in sIBM, we tested the effects of targeting this feature of the disease. Using rat myoblast… (More)
DOI: 10.1126/scitranslmed.aad4583

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