Targeting protein aggregation for the treatment of degenerative diseases

  title={Targeting protein aggregation for the treatment of degenerative diseases},
  author={Yvonne S. Eisele and Cecilia Monteiro and Colleen Fearns and Sandra E Encalada and R Luke Wiseman and Evan T Powers and Jeffery W Kelly},
  journal={Nature Reviews Drug Discovery},
The aggregation of specific proteins is hypothesized to underlie several degenerative diseases, which are collectively known as amyloid disorders. However, the mechanistic connection between the process of protein aggregation and tissue degeneration is not yet fully understood. Here, we review current and emerging strategies to ameliorate aggregation-associated degenerative disorders, with a focus on disease-modifying strategies that prevent the formation of and/or eliminate protein aggregates… CONTINUE READING
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