Targeting proteases: successes, failures and future prospects

@article{Turk2006TargetingPS,
  title={Targeting proteases: successes, failures and future prospects},
  author={Boris Turk},
  journal={Nature Reviews Drug Discovery},
  year={2006},
  volume={5},
  pages={785-799}
}
Key PointsProteases catalyse the hydrolyis of peptide bonds in proteins, often in a very precise way, and are thereby involved in the control of a number of important physiological processes including cell-cycle progression, DNA replication, cell proliferation and cell death, as well as the immune responseProtease signalling varies from a simple direct cleavage of a substrate to a complex cascade organization or a protease network, and requires tight regulationExcessive proteolytic activity… CONTINUE READING
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