Targeting prostate-specific membrane antigen for personalized therapies in prostate cancer: morphologic and molecular backgrounds and future promises.

@article{Santoni2014TargetingPM,
  title={Targeting prostate-specific membrane antigen for personalized therapies in prostate cancer: morphologic and molecular backgrounds and future promises.},
  author={Matteo Santoni and Marina Scarpelli and Roberta Mazzucchelli and Antonio Lopez-Beltran and Liang Cheng and Stefano Cascinu and Rodolfo Montironi},
  journal={Journal of biological regulators and homeostatic agents},
  year={2014},
  volume={28 4},
  pages={
          555-63
        }
}
Prostate-specific membrane antigen (PSMA) is an integral, non-shed membrane glycoprotein that is highly expressed on prostate epithelial cells and strongly upregulated in prostate cancer (PCa). Prostatic neoplastic transformation results in the transfer of PSMA from the apical membrane to the luminal surface of the ducts. However, the role of PSMA in tumor angiogenesis and carcinogenesis is poorly understood. PSMA is characterized by folate hydrolase and carboxypeptidase activity and… CONTINUE READING
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