Targeting poly(ADP-ribose) polymerase activity for cancer therapy

  title={Targeting poly(ADP-ribose) polymerase activity for cancer therapy},
  author={Fr{\'e}d{\'e}rique M{\'e}gnin-Chanet and Marc Andrew Bollet and Janet Hall},
  booktitle={Cellular and Molecular Life Sciences},
Poly(ADP-ribosyl)ation is a ubiquitous protein modification found in mammalian cells that modulates many cellular responses, including DNA repair. The poly(ADP-ribose) polymerase (PARP) family catalyze the formation and addition onto proteins of negatively charged ADP-ribose polymers synthesized from NAD+. The absence of PARP-1 and PARP-2, both of which are… CONTINUE READING