Targeting phosphorylation of eukaryotic initiation factor-2α to treat human disease.


The unfolded protein response, also known as endoplasmic reticulum (ER) stress, has been implicated in numerous human diseases, including atherosclerosis, cancer, diabetes, and neurodegenerative disorders. Protein misfolding activates one or more of the three ER transmembrane sensors to initiate a complex network of signaling that transiently suppresses… (More)
DOI: 10.1016/B978-0-12-396456-4.00005-5


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