Targeting phosphatidylinositol 3-kinase-Akt through hepatocyte growth factor for cardioprotection.

@article{Madonna2013TargetingP3,
  title={Targeting phosphatidylinositol 3-kinase-Akt through hepatocyte growth factor for cardioprotection.},
  author={Rosalinda Madonna and Roberto Bolli and Gregg D. Rokosh and Raffaele De Caterina},
  journal={Journal of cardiovascular medicine},
  year={2013},
  volume={14 4},
  pages={249-53}
}
Several growth factors have been shown to protect the cardiomyocyte from the detrimental effects of acute ischemia-reperfusion injury, through the activation of a variety of cell-surface receptors and the subsequent recruitment of a number of intracellular signal transduction pathways. Among these growth factors, hepatocyte growth factor (HGF), also named as scatter factor, acts by recruiting the phosphatidylinositol 3-kinase (PI3K)-Akt signal transduction pathway, linked to cardioprotection… CONTINUE READING
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