Targeting pathological remodeling: concepts of cardioprotection and reparation.

@article{Weber2000TargetingPR,
  title={Targeting pathological remodeling: concepts of cardioprotection and reparation.},
  author={Karl T. Weber},
  journal={Circulation},
  year={2000},
  volume={102 12},
  pages={1342-5}
}
The myocardium is composed of cardiac myocytes, which are tethered within an extracellular scaffolding of fibrillar collagen. Myocytes are large; they occupy a major portion of tissue space. However, they number only a third of all cells in the myocardium; noncardiomyocytes constitute the remaining two-thirds of cells and include endothelial and vascular smooth muscle cells of the intramural coronary circulation and fibroblasts located in interstitial and perivascular spaces. 1,2 Ventricular… CONTINUE READING