Targeting pancreatitis blocks tumor-initiating stem cells and pancreatic cancer progression

@inproceedings{Mohammed2015TargetingPB,
  title={Targeting pancreatitis blocks tumor-initiating stem cells and pancreatic cancer progression},
  author={Altaf Mohammed and Naveena B. Janakiram and Venkateshwar Madka and Misty Brewer and Rebekah L. Ritchie and Stan A. Lightfoot and Gaurav Kumar and Michael Sadeghi and Jagan Mohan R Patlolla and Hiroshi Y Yamada and Zobeida Cruz-Monserrate and Randal May and Courtney W. Houchen and Vernon E. Steele and Chinthalapally V Rao},
  booktitle={Oncotarget},
  year={2015}
}
Recent development of genetically engineered mouse models (GEMs) for pancreatic cancer (PC) that recapitulates human disease progression has helped to identify new strategies to delay/inhibit PC development. We first found that expression of the pancreatic tumor-initiating/cancer stem cells (CSC) marker DclK1 occurs in early stage PC and in both early and late pancreatic intraepithelial neoplasia (PanIN) and that it increases as disease progresses in GEM and also in human PC. Genome-wide next… CONTINUE READING

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