Targeting pain-depressed behaviors in preclinical assays of pain and analgesia: drug effects on acetic acid-depressed locomotor activity in ICR mice.

@article{Stevenson2009TargetingPB,
  title={Targeting pain-depressed behaviors in preclinical assays of pain and analgesia: drug effects on acetic acid-depressed locomotor activity in ICR mice.},
  author={Glenn W. Stevenson and Jim Cormier and Hannah K. Mercer and Chloe M. Adams and Catherine Page Dunbar and S. Stevens Negus and Edward J. Bilsky},
  journal={Life sciences},
  year={2009},
  volume={85 7-8},
  pages={309-15}
}
AIMS Pain depresses expression of many behaviors, and one goal of analgesic treatment is to restore pain-depressed behaviors. Assays that focus on pain-depressed behaviors may contribute to preclinical assessment of candidate analgesics. MAIN METHODS This study compared effects of the mu opioid receptor agonist morphine (an acknowledged analgesic), the dopamine receptor antagonist haloperidol (a non-analgesic sedative), the adenosine receptor antagonist caffeine (a non-analgesic stimulant… CONTINUE READING