Targeting oxidative stress in embryonal rhabdomyosarcoma.

  title={Targeting oxidative stress in embryonal rhabdomyosarcoma.},
  author={Xiang Chen and Elizabeth Stewart and Anang A. Shelat and Chunxu Qu and Armita Bahrami and Mark E. Hatley and Gang Wu and Cori L. Bradley and Justina D. McEvoy and Alberto S. Pappo and Sheri L. Spunt and Marcus B. Valentine and Virginia Valentine and Fred Krafcik and Walter H. Lang and Monika Wierdl and Lyudmila G. Tsurkan and Viktor Tolleman and Sara M. Federico and Chris Morton and Charles Lu and Li Ding and John Easton and Michael Rusch and Panduka Nagahawatte and Jianmin Wang and Matthew E Parker and Lei Wei and Erin K. Hedlund and David B. Finkelstein and Michael N Edmonson and Sheila Shurtleff and Kristy Lynn Boggs and Heather L. Mulder and Donald Albert Yergeau and Steve Skapek and Douglas S Hawkins and N. Carlos Ram{\'i}rez and Philip G. Potter and John A. Sandoval and Andrew M. Davidoff and Elaine R. Mardis and Richard K. Wilson and Jinghui Zhang and James R. Downing and Michael A. Dyer},
  journal={Cancer cell},
  volume={24 6},
Rhabdomyosarcoma is a soft-tissue sarcoma with molecular and cellular features of developing skeletal muscle. Rhabdomyosarcoma has two major histologic subtypes, embryonal and alveolar, each with distinct clinical, molecular, and genetic features. Genomic analysis shows that embryonal tumors have more structural and copy number variations than alveolar tumors. Mutations in the RAS/NF1 pathway are significantly associated with intermediate- and high-risk embryonal rhabdomyosarcomas (ERMS). In… CONTINUE READING
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