Targeting oxidative stress in cancer.

  title={Targeting oxidative stress in cancer.},
  author={Matthew W. Lawless and Kenneth J O'byrne and Steven G Gray},
  journal={Expert opinion on therapeutic targets},
  volume={14 11},
IMPORTANCE OF THE FIELD Reactive oxygen species (ROS) occur as natural by-products of oxygen metabolism and have important cellular functions. Normally, the cell is able to maintain an adequate balance between the formation and removal of ROS either via anti-oxidants or through the use specific enzymatic pathways. However, if this balance is disturbed, oxidative stress may occur in the cell, a situation linked to the pathogenesis of many diseases, including cancer. AREAS COVERED IN THIS… CONTINUE READING
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