Targeting oncolytic adenoviral agents to the epidermal growth factor pathway with a secretory fusion molecule.

@article{Hemminki2001TargetingOA,
  title={Targeting oncolytic adenoviral agents to the epidermal growth factor pathway with a secretory fusion molecule.},
  author={Akseli Hemminki and Igor Dmitriev and Bolin Liu and Renee Ann Desmond and Ramon Alemany and David T. Curiel},
  journal={Cancer research},
  year={2001},
  volume={61 17},
  pages={6377-81}
}
Cancer gene therapy with conditionally replicating adenoviruses is a powerful way of overcoming low tumor transduction. However, one of the main remaining obstacles is the highly variable level of the coxsackie-adenovirus receptor expression on human primary cancers. In contrast, the epidermal growth factor receptor (EGFR) is overexpressed in various tumor types, and its expression correlates with metastatic behavior and poor prognosis. We constructed an adenovirus expressing a secretory… CONTINUE READING

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