Targeting oncogenic Ras signaling in hematologic malignancies.

  title={Targeting oncogenic Ras signaling in hematologic malignancies.},
  author={Ashley F. Ward and Benjamin S. Braun and Kevin M. Shannon},
  volume={120 17},
Ras proteins are critical nodes in cellular signaling that integrate inputs from activated cell surface receptors and other stimuli to modulate cell fate through a complex network of effector pathways. Oncogenic RAS mutations are found in ∼25% of human cancers and are highly prevalent in hematopoietic malignancies. Because of their structural and biochemical properties, oncogenic Ras proteins are exceedingly difficult targets for rational drug discovery, and no mechanism-based therapies exist… CONTINUE READING


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