Targeting oncogenic ALK and MET: a promising therapeutic strategy for glioblastoma

  title={Targeting oncogenic ALK and MET: a promising therapeutic strategy for glioblastoma},
  author={IV GeraldC.Wallace and Yaenette N. Dixon-Mah and William Alex Vandergrift and Swapan K Ray and Catherine P. Haar and Amber M. Mittendorf and Sunil. J. Patel and Naren Lal Banik and Pierre Giglio and Arabinda Das},
  journal={Metabolic Brain Disease},
Glioblastoma is the most common aggressive, highly glycolytic, and lethal brain tumor. In fact, it is among the most commonly diagnosed lethal malignancies, with thousands of new cases reported in the United States each year. Glioblastoma’s lethality is derived from a number of factors including highly active pro-mitotic and pro-metastatic pathways. Two factors increasingly associated with the intracellular signaling and transcriptional machinery required for such changes are anaplastic… CONTINUE READING
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