Targeting of the transcription factor STAT4 by antisense phosphorothioate oligonucleotides suppresses collagen-induced arthritis.

@article{Hildner2007TargetingOT,
  title={Targeting of the transcription factor STAT4 by antisense phosphorothioate oligonucleotides suppresses collagen-induced arthritis.},
  author={Kai M. Hildner and Peter Schirmacher and Imke Atreya and Maria Dittmayer and Brigitte Bartsch and Peter R. Galle and Stefan Wirtz and Markus Friedrich Neurath},
  journal={Journal of immunology},
  year={2007},
  volume={178 6},
  pages={
          3427-36
        }
}
The transcription factor STAT4 mediates signals of various proinflammatory cytokines, such as IL-12, IL-15, and IL-23, that initiate and stabilize Th1 cytokine production. Although Th1 cytokine production has been suggested to play a major pathogenic role in rheumatoid arthritis, the role of STAT4 in this disease is poorly understood. In this study, we demonstrate a key functional role of STAT4 in murine collagen-induced arthritis (CIA). In initial studies we found that STAT4 expression is… CONTINUE READING
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