Targeting of the non-mutated tumor antigen HER2/neu to mature dendritic cells induces an integrated immune response that protects against breast cancer in mice

@inproceedings{Wang2011TargetingOT,
  title={Targeting of the non-mutated tumor antigen HER2/neu to mature dendritic cells induces an integrated immune response that protects against breast cancer in mice},
  author={Bei Wang and Neeha Zaidi and Li-Zhen He and Lei Zhang and Janelle M Y Kuroiwa and Tibor Keler and Ralph Marvin Steinman},
  booktitle={Breast Cancer Research},
  year={2011}
}
Given their relative simplicity of manufacture and ability to be injected repeatedly, vaccines in a protein format are attractive for breast and other cancers. However, soluble human epidermal growth factor receptor (HER2)/neu protein as a vaccine has not been immunogenic. When protein is directly targeted to antigen uptake receptors, such as DEC205 (DEC), efficient processing and presentation of antigen take place. The aim of this study was to determine the immunogenicity of a HER2 protein… CONTINUE READING

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