Targeting of the actin cytoskeleton during infection by Salmonella strains.

@article{Guiney2005TargetingOT,
  title={Targeting of the actin cytoskeleton during infection by Salmonella strains.},
  author={Donald G. Guiney and Marc Lesnick},
  journal={Clinical immunology},
  year={2005},
  volume={114 3},
  pages={
          248-55
        }
}
Many bacterial pathogens produce virulence factors that alter the host cell cytoskeleton to promote infection. Salmonella strains target cellular actin in a carefully orchestrated series of interactions that promote bacterial uptake into host cells and the subsequent proliferation and intercellular spread of the organisms. The Salmonella Pathogenicity Island 1 (SPI1) locus encodes a type III protein secretion system (TTSS) that translocates effector proteins into epithelial cells to promote… CONTINUE READING

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