Targeting of the P2X7 receptor in pancreatic cancer and stellate cells

@inproceedings{Giannuzzo2016TargetingOT,
  title={Targeting of the P2X7 receptor in pancreatic cancer and stellate cells},
  author={Andrea Giannuzzo and Mara Saccomano and Joanna Napp and Maria Ellegaard and Frauke Alves and Ivana Novak},
  booktitle={International journal of cancer},
  year={2016}
}
The ATP-gated receptor P2X7 (P2X7R) is involved in regulation of cell survival and has been of interest in cancer field. Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer and new markers and therapeutic targets are needed. PDAC is characterized by a complex tumour microenvironment, which includes cancer and pancreatic stellate cells (PSCs), and potentially high nucleotide/side turnover. Our aim was to determine P2X7R expression and function in human pancreatic cancer cells in vitro as… CONTINUE READING